Clinical Trial

Dual-Target GPC3/B7-H3 CAR-NK Cells for Advanced HCC

Study acronym: DUET-HCC
Recruiting Phase 1/2
View on ClinicalTrials.gov →
Summary
open-label trial of an allogeneic dual-target CAR-NK product directed against GPC3 and B7-H3 for adults with advanced hepatocellular carcinoma. The design intentionally uses GPC3 as the primary target anchor because GPC3 is the dominant HCC cell-therapy antigen in current clinical development, while adding B7-H3 to reduce antigen escape and to broaden coverage across tumor and tumor-microenvironment compartments. The study first evaluates safety and dose-limiting toxicities, then expands at the recommended phase 2 dose.
Trial Details
NCT Number NCT07500220
Lead Sponsor Beijing Biotech
Conditions Advanced Hepatocellular Carcinoma (HCC), Metastatic Liver Cancer
Enrollment 30 participants
Start Date 2026-03-02
Primary Completion 2027-03-14 (estimated)
Study Completion 2028-03-17 (estimated)
Updated on ClinicalTrials.gov 2026-03-30