Clinical Trial

Perioperative Lidocaine for Lung Protection in Infants Undergoing Cardiac Surgery

Study acronym: PLICS
Not Yet Recruiting Phase 4
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Summary
Cardiopulmonary bypass-associated pulmonary injury is a common complication after infant cardiac surgery and may contribute to impaired oxygenation, prolonged mechanical ventilation, and longer intensive care stay. Lidocaine has anti-inflammatory and membrane-stabilizing properties and may attenuate perioperative lung injury. This investigator-initiated, randomized, placebo-controlled, double-blind trial will evaluate whether perioperative intravenous lidocaine reduces postoperative pulmonary injury in infants undergoing corrective non-palliative congenital cardiac surgery with cardiopulmonary bypass.
Trial Details
NCT Number NCT07499154
Lead Sponsor The Children's Hospital of Zhejiang University School of Medicine
Conditions Congenital Heart Disease, Postoperative Pulmonary Complications, Acute Lung Injury
Enrollment 320 participants
Start Date 2026-04-01
Primary Completion 2027-12-01 (estimated)
Study Completion 2027-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-03-30