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Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA CAR-NK Cell Injection for the Treatment of Refractory Pediatric Rheumatic Diseases

Study acronym: Cell therapy
StatusRecruiting
PhaseEarly Phase 1
Started2026-03-19
View on ClinicalTrials.gov ↗
A single arm, open-label pilot study is designed to determine the safety and effectiveness of anti-CD19/BCMA CAR-NK cell injection in patients with refractory pediatric rheumatic diseases.
Trial Details
NCT Number NCT07490041
Lead Sponsor The Children's Hospital of Zhejiang University School of Medicine
Collaborators: Rui Therapeutics Co., Ltd
Conditions Rheumatic Diseases, Pediatric Rheumatological Condition (i.e., Arthritis, SLE, Kawasaki's Disaese), Systemic Lupus Erythematosus (SLE), Connective Tissue Disease-associated Interstitial Lung Disease
Enrollment 36 participants
Start Date 2026-03-19
Primary Completion 2026-12-19 (estimated)
Study Completion 2027-12-19 (estimated)
Updated on ClinicalTrials.gov 2026-03-24