Clinical Trial

A Study of LY4395089 and Mirikizumab (LY3074828) Given Together and Mirikizumab (Alone) in Adults With Crohn's Disease

Recruiting Phase 2
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Summary
The main purpose of this study is to see how the safety and efficacy of a farnesoid X receptor (FXR) agonist (LY4395089), given together with mirikizumab compares with mirikizumab (alone) in adults with moderately to severely active Crohn's disease (CD). This study is part of the IIBD master protocol and will last approximately 62 weeks.
Protocol Amendment History 1 change
critical Recruitment opened 2026-05-20
Trial Details
NCT Number NCT07483099
Lead Sponsor Eli Lilly and Company
Conditions Crohn Disease
Enrollment 60 participants
Start Date 2026-05-04
Primary Completion 2027-06 (estimated)
Study Completion 2028-03 (estimated)
Updated on ClinicalTrials.gov 2026-08-06