Clinical Trial

A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

Study acronym: AMAZE 5
Recruiting Phase 3
View on ClinicalTrials.gov →
Summary
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight and knee osteoarthritis. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Protocol Amendment History 3 changes
notable Trial sites expanded: 76 -> 82 locations 2026-04-30
notable Primary completion pushed: 2028-06-19 -> 2028-08-14 2026-04-30
critical Recruitment opened 2026-04-28
Trial Details
NCT Number NCT07481630
Lead Sponsor Novo Nordisk A/S
Conditions Obesity, Knee Osteoarthritis (OA)
Enrollment 400 participants
Start Date 2026-04-13
Primary Completion 2028-08-14 (estimated)
Study Completion 2028-08-14 (estimated)
Updated on ClinicalTrials.gov 2026-07-09