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A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

Name: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain — clinical trial record (NCT07481630)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: AMAZE 5

StatusRecruiting

PhasePhase 3

SponsorNovo Nordisk A/S

Started2026-04-13

View on ClinicalTrials.gov ↗

The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight and knee osteoarthritis. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Amendment history 3 changes detected by DataLookout

2026-04-30

Trial sites expanded: 76 → 82 locations

2026-04-30

Primary completion pushed: 2028-06-19 → 2028-08-14

2026-04-28

Recruitment opened

Trial Details

NCT Number	NCT07481630
Lead Sponsor	Novo Nordisk A/S
Conditions	Obesity, Knee Osteoarthritis (OA)
Enrollment	400 participants
Start Date	2026-04-13
Primary Completion	2028-08-14 (estimated)
Study Completion	2028-08-14 (estimated)
Updated on ClinicalTrials.gov	2026-07-09