Progel Platinum for Air Leak Reduction After VATS Lobectomy for NSCLC

This multicenter randomized trial evaluates whether routine use of Progel Platinum surgical sealant on stapled fissure lines during VATS upper or lower lobectomy for NSCLC reduces pleural drainage duration compared with standard stapling alone. Secondary objectives include postoperative length of stay, incidence and duration of postoperative air leaks, residual pleural space, safety outcomes, and hospitalization costs.

NCT Number	NCT07479277
Lead Sponsor	Fondazione del Piemonte per l'Oncologia
Conditions	Non-Small Cell Lung Cancer, Postoperative Air Leak, NSCLC
Enrollment	160 participants
Start Date	2026-02-27
Primary Completion	2027-02-27 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-18