Local Radiofrequency Ablation Plus External Beam Radiation for the Treatment of Painful Thoracic and Lumbar Spine Tumors

This study looks at how well a combination of treatments helps reduce pain in people with tumors in the middle and lower back (thoracic and lumbar spine). All participants receive the same treatment, which includes a procedure to stabilize the spine (kyphoplasty), radiofrequency ablation will be with the Osteocool system and radiation therapy. The goal is to see how effective this combined approach is at relieving pain. The purpose of this study is to find out whether combining these three treatments provides better pain relief for patients with thoracic and lumbar spine tumors. This study is for adults who have cancer that has spread to the thoracic or lumbar spine and who report moderate to severe back pain (a pain score of 5 or higher on a 0-10 pain scale).

NCT Number	NCT07479199
Lead Sponsor	UNC Lineberger Comprehensive Cancer Center Collaborators: Medtronic
Conditions	Thoracic Neoplasms, Lumbar Neoplasm
Enrollment	70 participants
Start Date	2026-03-16
Primary Completion	2031-03-01 (estimated)
Study Completion	2031-03-01 (estimated)
Updated on ClinicalTrials.gov	2026-04-23