Clinical Trial

Low-glucose/High-fat Intake Dietary Regimen as a Tool for Empowering Diagnostic Accuracy of 2-[18F]FDG PET/CT in Lepidic-predominant Growth Lung Adenocarcinoma

Study acronym: KETO-FDG Lung
Recruiting
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Summary
This study evaluates whether a 7-day ketogenic dietary regimen before 2-\[18F\]FDG PET/CT can improve the diagnostic accuracy of imaging in adults with suspected or histologically confirmed lepidic-predominant lung adenocarcinoma (LPA). LPA frequently shows low glucose metabolism and may yield false-negative FDG PET/CT results. Approximately 30 participants will undergo a tailored ketogenic diet for 7 days before PET/CT. Imaging results will be compared with histopathology and additionally assessed against literature-reported diagnostic performance and a matched retrospective institutional cohort.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-03-13.
Trial Details
NCT Number NCT07479095
Lead Sponsor Fondazione del Piemonte per l'Oncologia
Conditions Lepidic-Predominant Lung Adenocarcinoma, Lung Adenocarcinoma
Enrollment 30 participants
Start Date 2025-07-03
Primary Completion 2026-12-30 (estimated)
Study Completion 2027-03-30 (estimated)
Updated on ClinicalTrials.gov 2026-03-20