Photobiomodulation, Heart Rate Variability, and Acute Stress

Photobiomodulation (PBM) is a form of light therapy that uses red or near-infrared light to influence biological processes. In prior studies, PBM has been shown to improve various physiological functions, including tissue repair, inflammation, and cognitive performance. However, little is known about its impact on autonomic nervous system regulation. Thus, the goal of this study is to evaluate the effects of PBM on vagal activity, as measured by heart rate variability (HRV), in healthy adults undergoing experimental stress.

NCT Number	NCT07475858
Lead Sponsor	Brigham and Women's Hospital Collaborators: Vielight Inc.
Conditions	Stress
Enrollment	40 participants
Start Date	2026-07-01
Primary Completion	2027-05-31 (estimated)
Study Completion	2027-08-31 (estimated)
Updated on ClinicalTrials.gov	2026-06-02