Teenthrive 2: Treatments for Improving Mood in Teens

In this study, we will conduct a pilot RCT of a yoga-based intervention (YBI) vs. group cognitive-behavioral therapy (gCBT) at two sites. We will recruit 48 adolescent participants each in Columbus, OH and Boston, MA (96 total). We have a priori targets for indices of feasibility and acceptability, including recruitment rate, retention for assessments, class attendance, interventionist fidelity to manuals, and participant satisfaction. We hypothesize that we will meet these metrics at both sites.

NCT Number	NCT07475845
Lead Sponsor	Butler Hospital Collaborators: National Center for Complementary and Integrative Health (NCCIH), Beth Israel Deaconess Medical Center, Nationwide Children's Hospital
Conditions	Depression in Adolescence
Enrollment	96 participants
Start Date	2026-06-15
Primary Completion	2027-12 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2026-06-10