Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1

Adult patients with primary or secondary central nervous system malignancies will be invited to undergo a baseline \[C-11\]-CS1P1 PET scan and a follow-up scan within 24 months of the baseline scan (preferably within 6-months post-treatment).The study will describe patterns of tracer uptake in tumors and normal brain and explore how these patterns relate to MRI findings, treatments received, and clinical outcomes.

NCT Number	NCT07462507
Lead Sponsor	Washington University School of Medicine
Conditions	Central Nervous System Cancer, Brain Metastases
Enrollment	104 participants
Start Date	2026-04-16
Primary Completion	2031-06-30 (estimated)
Study Completion	2033-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-21