A Virtual Reality E-cigarette Prevention and Emotion Regulation Intervention for Adolescents

This study will examine E-Invite Only VR, a novel school-based universal e-cigarette prevention intervention that uses virtual reality (VR) to deliver prevention and emotion regulation skills-building content to middle school students in real-world classrooms. If successful, E-invite Only VR has the potential to prevent adolescents from experiencing a multitude of poor health outcomes related to nicotine vaping, including cancer.

NCT Number	NCT07460622
Lead Sponsor	Yale University Collaborators: National Cancer Institute (NCI)
Conditions	E-cigarette Use/Vaping Prevention, Nicotine Dependence Prevention, Adolescent Mental Health
Enrollment	1,251 participants
Start Date	2026-10-01
Primary Completion	2028-06 (estimated)
Study Completion	2028-06 (estimated)
Updated on ClinicalTrials.gov	2026-03-10