e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most

The overarching goal of this study is to pilot an intervention in which older adults with mild cognitive impairment and dementia and the older adult's care partners are identified in primary care and provided with educational materials through the patient portal to engage the participant in deprescribing. The multicomponent intervention, e-Align, includes delivery of educational information through the patient portal, and a pharmacist-led intervention to align medications with patient and care partner goals and reduce use of central nervous system (CNS) potentially inappropriate medicines (PIM). This work will establish the preliminary data, methods, and partnerships to undertake a multisite embedded pragmatic clinical trial. The resulting triadic-based behavioral intervention will promote patient and care partner engagement, and foster care that aligns with patients' values, and promote improved health and well-being outcomes for people with cognitive impairment and the patient's care partners through deprescribing.

NCT Number	NCT07454824
Lead Sponsor	Johns Hopkins University Collaborators: National Institute on Aging (NIA)
Conditions	Dementia, Potentially Inappropriate Medication Use, Mild Cognitive Impairment (MCI)
Enrollment	100 participants
Start Date	2026-04-15
Primary Completion	2027-02-06 (estimated)
Study Completion	2027-02-06 (estimated)
Updated on ClinicalTrials.gov	2026-06-16