Selective Activation of the Adrenomedullin Receptors in Migraine

Adrenomedullin is a neuropeptide implicated in the pathogenesis of migraine. This study investigates whether its administration, after pre-treatment with erenumab (a CGRP-receptor blocking monoclonal antibody), can trigger migraine attacks in individuals with migraine without aura.

NCT Number	NCT07451769
Lead Sponsor	Danish Headache Center
Conditions	Migraine, Brain Diseases, Central Nervous System Diseases, Adrenomedullin, Pain, Peptides, Neuropeptides, Signs and Symptoms
Enrollment	26 participants
Start Date	2026-03-10
Primary Completion	2027-03-10 (estimated)
Study Completion	2032-12-20 (estimated)
Updated on ClinicalTrials.gov	2026-03-09