Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection

This is an multicenter study that will test the diagnostic accuracy of a blood test (i.e., a liquid biopsy) for the diagnosis of colorectal cancer (CRC), advanced adenomas (AAs), as well as Lynch-syndrome associated cancers. Additionally, a pre-planned analysis will evaluate the use of this liquid biopsy as a tool for molecular residual disease monitoring purposes.

NCT Number	NCT07450612
Lead Sponsor	San Raffaele University
Conditions	Colorectal Cancer, Adenoma Colon, Adenoma Colon Polyp, Colon Adenoma, Colo-rectal Cancer, Colon Disease, Colon Neoplasm, Lynch Syndrome +11 more
Enrollment	1,200 participants
Start Date	2024-01-01
Primary Completion	2031-01-15 (estimated)
Study Completion	2031-08-15 (estimated)
Updated on ClinicalTrials.gov	2026-03-04