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Targeted Nerve Injection to the Knee (Nerve to Vastus Medialis): Comparing Two Adductor Canal Block Approaches

StatusNot Yet Recruiting
PhasePhase 4
Started2027-01-01
View on ClinicalTrials.gov ↗

Amendment history

2026-08-26
minor
Study Status v1
Start date2026-07-01→2027-01-01
2026-02-25
minor
Original filing
455 trials monitored
See 53 trials at risk
This randomized, double-blinded volunteer study compares two ways of performing the adductor canal (AC) nerve block at the mid-thigh to see which approach more reliably numbs the anteromedial knee. One approach is the traditional AC block placed near the saphenous nerve; the other separately targets the nerve to vastus medialis (NVM) in addition to the saphenous nerve. Healthy adult participants receive both blocks in one visit (one on each leg), with the order randomized. The primary outcome is change in quadriceps strength (a proxy for vastus medialis anesthesia) measured by load-cell dynamometry. Secondary outcomes include cutaneous sensory mapping (pinprick and cold) and the percentage of a standardized, marked knee-incision line covered by sensory block. The study uses ultrasound guidance and a standard dose of chloroprocaine, with routine monitoring to minimize risks.
Trial Details
NCT Number NCT07444827
Lead Sponsor Duke University
Conditions Anesthesia, Local
Enrollment 25 participants
Start Date 2027-01-01
Primary Completion 2027-07-01 (estimated)
Study Completion 2027-12-01 (estimated)
Updated on ClinicalTrials.gov 2026-08-27