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PrP-targeting siRNA Safety & Mechanism Study

Study acronym: PRiSM
StatusRecruiting
PhasePhase 1
Started
View on ClinicalTrials.gov ↗

Record History

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  1. Site contacts updated at 1 of 5 sitesv7
  2. Study sites: 4 to 5
    • Start date changed from estimate of Apr 2026 to May 15, 2026
    v6
  3. Study sites: 3 to 4v5
  4. Study sites: 1 to 3v4
  5. Recruitment opened
    • Study sites: 0 to 1
    v3
  6. Study title shortened, about 2 wordsv2
  7. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The purpose of this trial is to evaluate safety, tolerability, pharmacokinetics and pharmacodynamic impact of PrP-siRNA in symptomatic prion disease patients.
Trial Details
NCT Number NCT07444580
Lead Sponsor Broad Institute of MIT and Harvard
Collaborators: National Institute of Neurological Disorders and Stroke (NINDS)
Conditions
(from sponsor)		 Prion Disease
Related terms Creutzfeldt-Jakob Syndrome, Gerstmann-Straussler-Scheinker Disease, Insomnia, Fatal Familial, Prion Diseases
Enrollment 30 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov