Clinical Trial

PrP-targeting siRNA Safety & Mechanism Study

Name: PrP-targeting siRNA Safety & Mechanism Study — clinical trial record (NCT07444580)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: PRiSM

Recruiting Phase 1

View on ClinicalTrials.gov →

Summary

The purpose of this trial is to evaluate safety, tolerability, pharmacokinetics and pharmacodynamic impact of PrP-siRNA in symptomatic prion disease patients.

Protocol Amendment History 1 change

critical Recruitment opened 2026-04-18

Trial Details

NCT Number	NCT07444580
Lead Sponsor	Broad Institute of MIT and Harvard Collaborators: National Institute of Neurological Disorders and Stroke (NINDS)
Conditions	Prion Disease
Enrollment	30 participants
Start Date	2026-05-15
Primary Completion	2029-08-14 (estimated)
Study Completion	2029-08-14 (estimated)
Updated on ClinicalTrials.gov	2026-06-05