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Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS

StatusRecruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗

Record History

  1. Phase changed: not applicable → Phase 2
    • Recruitment opened
    • Study sites: 0 to 1
    • Start date changed from estimate of May 1, 2026 to Jul 8, 2026
    v2
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study is focused on people with Parkinson's disease who already have deep brain stimulation devices. The goal is to understand how aerobic exercise, specifically forced vs voluntary cycling, affects movement, thinking, and brain activity in these individuals. Parkinson's disease is a progressive condition that impacts both movement and cognitive function. Previous research suggests aerobic exercise can improve PD symptoms, but the mechanisms underlying the improvement are not fully understood. This study aims to evaluate the neural (brain) mechanisms underlying exercise.
Trial Details
NCT Number NCT07442747
Lead Sponsor The Cleveland Clinic
Collaborators: National Institute on Aging (NIA)
Conditions
(from sponsor)		 Parkinson's Disease, Deep Brain Stimulation
Related terms Motor Activity, Parkinson Disease
Enrollment 36 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov