Clinical Trial

The Per-procedural Antibiotic Prophylaxis in Patients Undergoing Transcatheter Aortic Valve Implantation Trial

Study acronym: PAPPI
Not Yet Recruiting
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Summary
The study is a prospective, crossover, cluster randomized trial in patients undergoing transcatheter aortic valve implantation (TAVI). The study tests whether cephalosporin plus beta-lactam antibiotic with spectrum for Enterococcus faecalis as per procedural prophylaxis is superior to cephalosporin alone in reducing the composite outcome of bacteremia or death at 6 months post-TAVI.
Trial Details
NCT Number NCT07442357
Lead Sponsor Rigshospitalet, Denmark
Conditions Aortic Valve Stenosis
Enrollment 1,986 participants
Start Date 2026-06-01
Primary Completion 2029-06-01 (estimated)
Study Completion 2029-06-01 (estimated)
Updated on ClinicalTrials.gov 2026-03-02