Clinical Trial

A Clinical Trial in Healthy Participants to Learn How Itraconazole Affects MK-2828 Levels and How MK-2828 Affects Midazolam Levels (MK-2828-007)

Active, Not Recruiting Phase 1
View on ClinicalTrials.gov →
Record status
This record was last updated August 6, 2026 (before its estimated August 12, 2026 completion). Its status may not reflect the trial's current state.
Summary
The main goals of this study are: * To learn what happens to one dose of MK-2828 in a healthy person's body over time when it is taken with itraconzole * To learn what happens to one dose of midazolam in a healthy person's body over time when it is taken with MK-2828 Researchers want to learn if the levels of MK-2828 in the body are about the same when MK-2828 is taken with itraconazole as when it is taken alone. They also want to know if taking MK-2828 more than once affects how much midazolam is in the body after a single dose.
Protocol Amendment History 1 change
critical Enrollment closed, study ongoing 2026-08-07
Trial Details
NCT Number NCT07435194
Lead Sponsor Merck Sharp & Dohme LLC
Conditions Healthy
Enrollment 28 participants
Start Date 2026-03-06
Primary Completion 2026-08-12 (estimated)
Study Completion 2026-08-12 (estimated)
Updated on ClinicalTrials.gov 2026-08-06