Impact of C-Mill Rehabilitation on the Gut-Brain Axis in Parkinson's Disease

The GM-REHAB-2025 study aims to evaluate the impact of physiotherapy interventions using the C-Mill treadmill, with and without semi-immersive virtual reality, on gut microbiota and metabolic parameters in patients with Parkinson's disease. Three groups will be involved: one undergoing conventional physiotherapy, one treated with the C-Mill without virtual reality (VR), and one treated with C-Mill technology combined with VR. Clinical assessments and the collection of biological samples (stool, serum, and plasma) will be carried out at three time points: at baseline, at the end of treatment (21 days), and after 3 months.

NCT Number	NCT07434089
Lead Sponsor	IRCCS Centro Neurolesi Bonino Pulejo Collaborators: Università degli studi di Messina
Conditions	Parkinson Disease
Enrollment	60 participants
Start Date	2025-10-20
Primary Completion	2027-10-20 (estimated)
Study Completion	2028-10-20 (estimated)
Updated on ClinicalTrials.gov	2026-02-25