Prognostic Value of SII and SIRI in Obesity-Related Metabolic Complications

This observational study aims to evaluate the diagnostic and prognostic value of the systemic immune-inflammatory index (SII) and the systemic inflammation response index (SIRI) in individuals with overweight or obesity. The study will assess their association with obesity status, metabolic complications, lifestyle patterns, dietary indices, and established inflammatory biomarkers. Participants will undergo anthropometric assessment, laboratory testing, dietary evaluation, and follow-up for response to different obesity treatment modalities over 3 years. The study intends to determine whether SII and SIRI can serve as clinically useful predictors of metabolic risk and treatment outcomes of obesity.

NCT Number	NCT07431593
Lead Sponsor	University of Rijeka
Conditions	Overweight and Obesity, Inflammation, Metabolic Syndrome
Enrollment	200 participants
Start Date	2026-04
Primary Completion	2027-04-28 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-05-07