Clinical Trial

SPARK Study - Sympathetic Periarterial Radial Block in Healthy Volunteers

Study acronym: SPARK
Not Yet Recruiting Phase 4
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Summary
The SPARK Study evaluates changes in peripheral sympathetic vasomotor activity following a targeted, ultrasound-guided periarterial sympathetic block of the distal radial artery in healthy volunteers. Autonomic reactivity will be assessed before and after the block using digit-specific pulse-amplitude index and infrared thermography during standardized cold pressor testing.
Protocol Amendment History 1 change
critical Phase changed: not applicable -> Phase 4 2026-04-02
Trial Details
NCT Number NCT07429292
Lead Sponsor Duke University
Conditions Healthy Volunteers, Sympathetic Activity
Enrollment 20 participants
Start Date 2026-09
Primary Completion 2026-12 (estimated)
Study Completion 2027-04 (estimated)
Updated on ClinicalTrials.gov 2026-06-17