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SPARK Study - Sympathetic Periarterial Radial Block in Healthy Volunteers

Study acronym: SPARK
StatusNot Yet Recruiting
PhasePhase 4
Started2026-09
View on ClinicalTrials.gov ↗

Amendment history

2026-06-16
minor
Study Status v2
Start date2026-05→2026-09
2026-03-27
notable
Study Status, Oversight, Study Design, Contacts/Locations v1
Phase changed: not applicable → Phase 4
Study sites0→1
2026-02-18
minor
Original filing
455 trials monitored
See 53 trials at risk
The SPARK Study evaluates changes in peripheral sympathetic vasomotor activity following a targeted, ultrasound-guided periarterial sympathetic block of the distal radial artery in healthy volunteers. Autonomic reactivity will be assessed before and after the block using digit-specific pulse-amplitude index and infrared thermography during standardized cold pressor testing.
Trial Details
NCT Number NCT07429292
Lead Sponsor Duke University
Conditions Healthy Volunteers, Sympathetic Activity
Enrollment 20 participants
Start Date 2026-09
Primary Completion 2026-12 (estimated)
Study Completion 2027-04 (estimated)
Updated on ClinicalTrials.gov 2026-06-17