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A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients

StatusRecruiting
PhasePhase 4
Started2026-09-14
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 9 months later Feb 2027 → Dec 2027
See other at-risk trials from Mayo Clinic

Amendment history

2026-09-22
Recruitment opened
2026-09-08
Study Status v4
Re-verified, no change to tracked fields
2026-07-31
Study Status v3
Primary completion pushed: 2027-02 → 2027-12
Completion pushed: 2027-08 → 2028-06
Start date2026-07→2026-09
2026-06-11
Study Status v2
Start date2026-05→2026-07
2026-04-22
Study Status v1
Start date2026-02→2026-05
2026-02-14
Original filing
Mayo Clinic
1,015 trials monitored
See 115 trials at risk
The purpose of this research is to determine if two commonly used medications to treat metabolic acidosis in the setting of cardiac surgery, sodium bicarbonate and THAM, are equivalent.
Trial Details
NCT Number NCT07424625
Lead Sponsor Mayo Clinic
Conditions Metabolic Acidosis
Enrollment 250 participants
Start Date 2026-09-14
Primary Completion 2027-12 (estimated)
Study Completion 2028-06 (estimated)
Updated on ClinicalTrials.gov 2026-09-21