Clinical Trial

T4/T3 Therapy in Hypothyroidism

Not Yet Recruiting Phase 2
View on ClinicalTrials.gov →
Summary
This study will test whether 6 months of combination therapy with levothyroxine (LT4) plus liothyronine (LT3) is superior to LT4 plus placebo in participants with hypothyroidism who have residual symptoms of hypothyroidism with TSH levels within the reference range.
Protocol Amendment History 2 changes
notable Primary completion pushed: 2027-03 -> 2027-06 2026-04-22
minor Completion pushed: 2027-03 -> 2027-06 2026-04-22
Trial Details
NCT Number NCT07424183
Lead Sponsor University of Pennsylvania
Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions Hypothyroidism Primary
Enrollment 60 participants
Start Date 2026-06
Primary Completion 2027-06 (estimated)
Study Completion 2027-06 (estimated)
Updated on ClinicalTrials.gov 2026-04-21