Clinical Trial

PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE)

Study acronym: PRECEDENCE
Recruiting
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Summary
The PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE) study is a pilot feasibility trial evaluating the implementation of pre-hospital targeted temperature management (TTM) using a wearable surface cooling device (CarbonCool® vest) in adult out-of-hospital cardiac arrest (OHCA) patients with return of spontaneous circulation (ROSC). The study aims to assess feasibility, fidelity, acceptability, and safety of initiating cooling in the field by emergency medical services (EMS) prior to hospital arrival. Results will inform the design of a larger definitive trial to determine the clinical effectiveness of early pre-hospital TTM in improving neurological outcomes.
Protocol Amendment History 1 change
critical Recruitment opened 2026-04-30
Trial Details
NCT Number NCT07421882
Lead Sponsor Singapore General Hospital
Collaborators: Singapore Civil Defence Force, National University Heart Centre, Singapore
Conditions Out-Of-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation, Death, Sudden, Cardiac, Therapeutic Hypothermia
Enrollment 50 participants
Start Date 2026-02-01
Primary Completion 2026-12 (estimated)
Study Completion 2027-03 (estimated)
Updated on ClinicalTrials.gov 2026-04-29