Clinical Trial

Neuroma-Associated Pain Management After Combat-Related Trauma in Ukraine

Study acronym: NAP-C/R
Recruiting
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Summary
This multicenter interventional study in Ukraine is designed to compare the effectiveness of cryoablation and radiofrequency ablation in managing neuroma-associated pain following combat-related trauma. Adult patients with clinically significant neuropathic pain caused by neuromas will be randomly assigned to receive either image-guided cryoablation or radiofrequency ablation of the affected nerve. Cryoablation uses controlled cold temperatures to temporarily disrupt nerve conduction, while radiofrequency ablation uses thermal energy to modulate nerve function. Both interventions are minimally invasive and performed under image guidance. The study will evaluate changes in pain intensity, opioid consumption, functional outcomes, and patient-reported measures at predefined time points following the procedure. This research aims to provide evidence on which intervention is more effective in reducing pain, improving function, and minimizing the need for opioid medications in patients with combat-related neuroma pain.
Trial Details
NCT Number NCT07416448
Lead Sponsor Ukrainian Society of Regional Anesthesia and Pain Therapy
Conditions Pain Management, Quality of Life, Neuroma, Functional Outcome, Depression in Adults, Neuropathic Pain, Hypoesthesia
Enrollment 50 participants
Start Date 2026-02-05
Primary Completion 2027-02-05 (estimated)
Study Completion 2027-02-05 (estimated)
Updated on ClinicalTrials.gov 2026-02-18