Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke

This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory and brain injury laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large vessel occlusions and are treated with either current accepted management, or accepted management in addition to transcutaneous auricular vagal nerve stimulation.

NCT Number	NCT07404852
Lead Sponsor	Washington University School of Medicine
Conditions	Large Vessel Occlusion, Acute Ischemic Stroke
Enrollment	65 participants
Start Date	2026-02-23
Primary Completion	2027-11-29 (estimated)
Study Completion	2028-02-29 (estimated)
Updated on ClinicalTrials.gov	2026-04-13