Rewiring the Brain-Immune Axis for Chronic Pain Using Transcranial Magnetic Stimulation in Psoriatic Arthritis

Despite advances in immunomodulatory therapies, many Psoriatic arthritis (PsA) patients experience persistent pain unrelated to clinical active joint inflammation. Recent evidence suggests the Inferior Parietal Lobule (IPL) serves as a neuroimmune hub linking central neural activity with peripheral immune dysregulation. In a prior feasibility study, a single L-IPL-targeted TMS session reduced pain and altered immune signalling in inflammatory arthritis by reducing STAT3 phosphorylation in circulating monocytes. This study builds on those findings by evaluating whether rTMS over 4 weeks can induce sustained immune reprogramming while providing meaningful pain relief.

NCT Number	NCT07403890
Lead Sponsor	NHS Greater Glasgow and Clyde Collaborators: Chief Scientist Office of the Scottish Government
Conditions	Psoriatic Arthritis
Enrollment	40 participants
Start Date	2026-03-01
Primary Completion	2028-03-28 (estimated)
Study Completion	2028-03-28 (estimated)
Updated on ClinicalTrials.gov	2026-02-11