Fracture Risk in Living Kidney Donors

This study will be a population-based, matched retrospective cohort study using linked administrative healthcare databases from Ontario, Alberta, and British Columbia to evaluate the long-term risk of fractures among living kidney donors compared with a healthy cohort of nondonors. Living kidney donors who donated between 1992 and 2024 will be included and matched 1:10 to a carefully selected population of nondonors based on key demographic and clinical characteristics. The primary outcome is a composite of incident hip, femoral shaft, humeral, wrist/forearm, and pelvic fractures. Secondary outcomes will examine each fracture site separately. The results will provide evidence to inform clinical guidelines, support informed decision-making for potential donors and recipients, and guide counselling by transplant clinicians.

NCT Number	NCT07401953
Lead Sponsor	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Collaborators: Canadian Institutes of Health Research (CIHR)
Conditions	Living Kidney Donor, Living Kidney Donation, Fractures, Nephrectomy,Kidney Donation, Fragility Fractures
Enrollment	50,000 participants
Start Date	1992-07-01
Primary Completion	2024-03-31 (estimated)
Study Completion	2025-03-31 (estimated)
Updated on ClinicalTrials.gov	2026-02-13