MCSPNCT07400393

Healey ALS MyMatch Common Screening Protocol

StatusRecruiting

PhaseNot specified

SponsorMassachusetts General Hospital

Primary completionMar 16, 2029 (estimated)

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Record History

All 3 versions: 3 with changes below. See every version on ClinicalTrials.gov ↗

Notable Nov 9, 2026 Recruitment opened Show 4 more changesShow less
- Eligibility criteria expanded, about 23 words
- Trial sites expanded: 0 → 4 locations
- Start date changed from estimate of Aug 2026 to Aug 31, 2026
- Study description expanded, about 222 words
Notable Jul 28, 2026 Start date: Mar 16, 2026 to Aug 2026v2
Feb 6, 2026 Study First Submitted

Notable: the plan changed

Endpoints

Primary

Preliminary eligibility to be matched to a MyMatch Trial

Timeframe: From enrollment to the end of the 45-day MCSP screening period or at the end of completing a baseline visit for a MyMatch trial.

Secondary (3)

Repository for future research

Prevalence of gene mutations

Collect and bank samples

Sites

4 sites in 1 country

About this trial

The Healey ALS MyMatch Common Screening Protocol (MCSP) is an observational study. The main goal of the study is to help connect adults living with ALS to Healey ALS MyMatch interventional clinical trials that may be a good fit for them. People who complete an MCSP Screening Visit will undergo: * clinical assessments * laboratory testing * biomarker analyses The above will be used to determine preliminary eligibility for enrolling ALS MyMatch trials. In addition to helping connect people to a Healey ALS MyMatch interventional clinical trial, the information will also be used to characterize clinical, genetic, and biofluid biomarker profiles. These profiles will help to match the right people to the right trials and evaluate the frequency of ALS-associated gene variants. Blood samples and DNA will also be stored for future ALS and biomarker research.

Trial details

Enrollment: 500 participants (estimated)
Started: Aug 31, 2026
Study completion: Mar 16, 2029 (estimated)
Eligibility: 18 and older, all sexes, no healthy volunteers
Design: Observational
Oversight: No data monitoring committee
Conditions: Amyotrophic Lateral Sclerosis, ALS, ALS (Amyotrophic Lateral Sclerosis)
Official title: Healey ALS MyMatch Common Screening Protocol (MCSP) for Determining Preliminary Eligibility for ALS MyMatch Early Phase Clinical Trials
First posted: Feb 10, 2026
Registry updated: Nov 12, 2026
Last verified: Oct 2026

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