Clinical Trial

A Phase I Dose Escalation and Dose Expansion Study to Investigate the Pharmacokinetics and Safety of Subcutaneous Durvalumab

Study acronym: IMFINZI-subQ
Recruiting Phase 1
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Summary
The purpose of the study is to determine a subcutaneous (SC: under the skin) durvalumab + recombinant human hyaluronidase (rHu) dose that yields systemic drug exposure similar to intravenous (IV: into the veins) durvalumab administration and to evaluate the pharmacokinetics and safety of SC durvalumab + rHu injection in participants with different types of solid tumours (cancers).
Protocol Amendment History 1 change
critical Recruitment opened 2026-04-18
Trial Details
NCT Number NCT07391670
Lead Sponsor AstraZeneca
Conditions Solid Tumours
Enrollment 40 participants
Start Date 2026-03-31
Primary Completion 2027-08-30 (estimated)
Study Completion 2027-08-30 (estimated)
Updated on ClinicalTrials.gov 2026-07-13