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NotableRecruitment resumed after suspensionEligibility criteria expanded, about 12 words · Secondary endpoints: details revised at 1 of 2 entries · Study description expanded, about 14 words · 1 moreShow 4 more changesShow less
Eligibility criteria expanded, about 12 words
Secondary endpoints: details revised at 1 of 2 entries
Study description expanded, about 14 words
Site details revised
Minor3 versionsRe-verified since Jul 3, 2026, no change to tracked fieldsv33-v35
StoppedRecruitment suspendedSponsor's reason: New recruitment on hold for a protocol design amendment/modification.Site details revisedv32Show 1 more changeShow less
Site details revised
MinorStart date changed from estimate of Apr 2, 2026 to Mar 26, 2026v31
Show 29 earlier versionsHide 29 earlier versions
MinorStart date: Apr 1, 2026 to Apr 2, 2026v30
MinorStart date: Mar 31, 2026 to Apr 1, 2026v29
MinorStart date: Mar 30, 2026 to Mar 31, 2026v28
MinorStart date: Mar 29, 2026 to Mar 30, 2026v27
MinorStart date: Mar 26, 2026 to Mar 29, 2026v26
MinorStart date: Mar 25, 2026 to Mar 26, 2026v25
NotableTrial status: Not Yet Recruiting to RecruitingStart date: Mar 23, 2026 to Mar 25, 2026 · Site details revisedv24Show 2 more changesShow less
Start date: Mar 23, 2026 to Mar 25, 2026
Site details revised
MinorStart date: Mar 22, 2026 to Mar 23, 2026v23
MinorStart date: Mar 19, 2026 to Mar 22, 2026v22
MinorStart date: Mar 18, 2026 to Mar 19, 2026v21
MinorStart date: Mar 17, 2026 to Mar 18, 2026v20
MinorStart date: Mar 16, 2026 to Mar 17, 2026v19
MinorStart date: Mar 15, 2026 to Mar 16, 2026v18
MinorStart date: Mar 12, 2026 to Mar 15, 2026v17
MinorStart date: Mar 11, 2026 to Mar 12, 2026v16
MinorStart date: Mar 10, 2026 to Mar 11, 2026v15
MinorStart date: Mar 9, 2026 to Mar 10, 2026v14
MinorStart date: Mar 8, 2026 to Mar 9, 2026v13
MinorStart date: Mar 5, 2026 to Mar 8, 2026v12
MinorStart date: Mar 4, 2026 to Mar 5, 2026v11
MinorStart date: Mar 3, 2026 to Mar 4, 2026v10
MinorStart date: Mar 2, 2026 to Mar 3, 2026v9
MinorStart date: Mar 1, 2026 to Mar 2, 2026v8
MinorStart date: Feb 26, 2026 to Mar 1, 2026v7
MinorStart date: Feb 25, 2026 to Feb 26, 2026v6
MinorStart date: Feb 24, 2026 to Feb 25, 2026v5
MinorStart date: Feb 23, 2026 to Feb 24, 2026v4
MinorStart date: Feb 22, 2026 to Feb 23, 2026v3
MinorStart date: Feb 9, 2026 to Feb 22, 2026v2
MinorStudy First Submitted
Stopped: an ongoing trial was terminated, suspended or withdrawn.
Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Background:
T-cell lymphoma is a blood cancer that affects immune system cells. People tend to survive less than 1 year if this disease does not respond to treatment (is refractory) or comes back after treatment (relapses). Azacitidine and abatacept are 2 drugs that are used to treat other diseases. Researchers want to know if these drugs, used together, can help people with T-cell lymphoma.
Objective:
To learn if azacitidine combined with abatacept can shrink tumors in people with T-cell lymphoma.
Eligibility:
People aged 18 years and older with T-cell lymphoma that either came back or did not respond to treatment.
Design:
Participants will be screened. They will have a physical exam with blood tests. They will have a test of their heart function. They will have imaging scans of their tumors. A sample of tumor tissue may be taken.
Azacitidine is injected under the skin of the thigh, abdomen, or upper arm. Abatacept is infused through a needle inserted into a vein in the arm.
Participants will receive the study drugs in 28-day cycles for up to 13 cycles. They will come to the clinic for each treatment. They will come to the clinic on day 1 and day 15 of the first cycle. After that, they will come to the clinic on the first 5 or 7 days of each cycle. Each clinic visit will take no more than 8 hours.
Imaging scans and other tests will be repeated during the study. Participants will have follow-up visits for up to 5 years after they stop taking the study drugs....