Clinical Trial

Study of Lesion-Specific Invasive Haemodynamic Angina Thresholds

Study acronym: ORBITA-SOLAR
Recruiting
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Summary
ORBITA-SOLAR is an invasive physiological cardiac catheterisation study that aims to determine whether different coronary stenoses have different angina thresholds. The angina threshold is defined as the amount of coronary flow reduction required to reproduce symptoms. Sixty patients with symptoms of stable angina and 2 coronary artery stenoses amenable to percutaneous coronary intervention (PCI) will be recruited. This study will use intra-coronary balloon inflation during supine exercise on an ergometer to measure the fractional flow reserve (FFR) and non-hyperemic pressure ratio (NHPR) that relates to angina onset, in real time, at the location of each stenosis.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2026-01-27; most recent amendment 2026-06-23.
Status change: Not Yet Recruiting → Recruiting 2026-02-16
Trial Details
NCT Number NCT07386418
Lead Sponsor Imperial College London
Collaborators: St George's University Hospitals NHS Foundation Trust, Royal Free Hospital NHS Foundation Trust, University Hospitals Dorset NHS Foundation Trust, Mid and South Essex NHS Foundation Trust, Imperial College Healthcare NHS Trust, Chelsea and Westminster NHS Foundation Trust, Guy's and St Thomas' NHS Foundation Trust, Liverpool Heart and Chest Hospital NHS Foundation Trust
Conditions Angina (Stable), Coronary Artery Disease(CAD), Ischaemic Heart Disease (IHD)
Enrollment 60 participants
Start Date 2026-02-10
Primary Completion 2028-12 (estimated)
Study Completion 2028-12 (estimated)
Updated on ClinicalTrials.gov 2026-06-26