Melatonin for Glycemic Control in Gestational Diabetes Mellitus

The goal of this randomized, double-blind, placebo-controlled clinical trial is to evaluate whether melatonin supplementation improves glycemic control in pregnant women diagnosed with gestational diabetes mellitus (GDM). The main question it aims to answer is: Does melatonin supplementation help with glycemic control, especially in lowering fasting plasma glucose level? Researchers will compare melatonin to a placebo (a look-alike substance that contains no melatonin) to see if melatonin works to improve glycemic control. Participants will: 1. Take melatonin or a placebo every day after randomization until delivery 2. Visit the antenatal clinic once every 1 to 2 weeks for follow-ups

NCT Number	NCT07369284
Lead Sponsor	Obstetrics & Gynecology Hospital of Fudan University Collaborators: West China Second University Hospital
Conditions	Gestational Diabetes
Enrollment	150 participants
Start Date	2026-02
Primary Completion	2027-06 (estimated)
Study Completion	2027-08 (estimated)
Updated on ClinicalTrials.gov	2026-01-27