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AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

Study acronym: AMAZE 1
StatusRecruiting
PhasePhase 3
Started2026-02-24
View on ClinicalTrials.gov ↗
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Amendment record

Amended 5 times since 2026-01-13; most recent filed 2026-07-08. Every amendment is listed below.

Dates here are the day the sponsor filed the amendment, not the day ClinicalTrials.gov published it. Version history last read from ClinicalTrials.gov on 2026-08-31.

2026-07-08
Amendment Study Status, Contacts/Locations v5
2026-06-01
Amendment Study Status, Contacts/Locations v4
2026-05-12
Amendment Study Status, Contacts/Locations v3
2026-04-06
Amendment Study Status, Contacts/Locations v2
2026-03-02
Amendment Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v1
2026-01-13
Original filing
Trial Details
NCT Number NCT07339423
Lead Sponsor Novo Nordisk A/S
Conditions Obesity
Enrollment 1,150 participants
Start Date 2026-02-24
Primary Completion 2029-06-26 (estimated)
Study Completion 2029-08-21 (estimated)
Updated on ClinicalTrials.gov 2026-07-09