Robotic vs Laparoscopic Gastrectomy for cT4a Gastric Cancer

The goal of this multicenter, randomized, phase III clinical trial is to test whether robot-assisted radical gastrectomy improves 3-year recurrence-free survival versus laparoscopy-assisted radical gastrectomy in adults aged 18-80 years with previously untreated, resectable cT4a gastric adenocarcinoma and non-bulky lymph nodes; the main questions are whether the robotic approach confers superior RFS and maintains equivalent peri-operative safety (Clavien-Dindo ≥ II complications) and better secondary oncologic outcomes, and participants will be randomized 1:1 to undergo standardized D2 resection via robotic or laparoscopic technique and followed for 5 years with scheduled recurrence, survival, and quality-of-life assessments.

NCT Number	NCT07331454
Lead Sponsor	The First Affiliated Hospital with Nanjing Medical University Collaborators: First Affiliated Hospital of Suzhou Medical College, The Affiliated Hospital of Xuzhou Medical University, The Affiliated Jiangning Hospital of Nanjing Medical University
Conditions	Gastric Cancer (GC)
Enrollment	335 participants
Start Date	2026-02-01
Primary Completion	2030-12-31 (estimated)
Study Completion	2031-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-01-12