Study of PNPLA3 Genetic Polymorphisms in Patients With Non-Alcoholic Fatty Liver Disease in an Ultramarine Population (AdipoDROMExpo)

Metabolic Dysfunction Associated Liver Disease (MASLD) is associated with metabolic syndrome, and PNPLA3 variants are known to be implicated in intrahepatic lipid accumulation and linked to lipotoxicity. Analysis of PNPLA3 polymorphisms in an overseas territories population of MASLD would be interesting to describe their profile susceptibility to develop Metabolic dysfunction associated steatohepatitis (MASH).

NCT Number	NCT07330830
Lead Sponsor	Centre Hospitalier Universitaire de la Guadeloupe Collaborators: Centre Hospitalier Universitaire de la Réunion
Conditions	MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis)
Enrollment	600 participants
Start Date	2025-11-26
Primary Completion	2027-11-26 (estimated)
Study Completion	2027-11-28 (estimated)
Updated on ClinicalTrials.gov	2026-01-09