Hypofractionated Radiotherapy With a Focal Microboost for High-Risk and Locally Advanced Prostate Cancer

This study is for adult men with previously untreated high risk, very high risk, or pelvic lymph node positive prostate cancer. The purpose of this study is to evaluate the safety and effectiveness of the combination of two emerging radiation treatment techniques (hypofractionated radiotherapy and microboost technique). Participation will include standard of care visits along with questionnaires and blood draws completed for research purposes. There is optional banking of blood and prostate biopsy tissue which will not require extra biopsies. Participation in this study is anticipated to last approximately 6 weeks with follow up every three months for two years then twice yearly for years 3-5.

NCT Number	NCT07325721
Lead Sponsor	Medical University of South Carolina
Conditions	Prostate Cancer, Prostate Cancer Patients Treated by Radiotherapy
Enrollment	46 participants
Start Date	2026-02-02
Primary Completion	2029-01-01 (estimated)
Study Completion	2034-01-01 (estimated)
Updated on ClinicalTrials.gov	2026-02-05