A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia

In this study, the investigators will follow two small cohorts of pregnant women: a cohort of healthy women with uncomplicated pregnancies residing at high altitude, a control group of healthy women with uncomplicated pregnancies residing at sea level, to characterize differences in cardiopulmonary adaptation and nitric oxide (NO) pathway expression at elevations \>3,500 m throughout pregnancy and into the postpartum period. The investigators aim to investigate right-sided cardiac impairment induced by chronic hypobaric hypoxemia, its effects on fetal growth, and the potential contribution of cardiovascular nitric oxide depletion to obstetric complications.

NCT Number	NCT07312227
Lead Sponsor	Massachusetts General Hospital
Conditions	Hypertensive Disorder of Pregnancy, Pulmonary Arterial Hypertension, Intrauterine Growth Restriction
Enrollment	27 participants
Start Date	2026-02-11
Primary Completion	2026-12 (estimated)
Study Completion	2027-02 (estimated)
Updated on ClinicalTrials.gov	2026-05-26