Clinical Trial

Creatine and Perioperative Brain Health

Study acronym: CREATE
Not Yet Recruiting
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Summary
The overall goal of this study is to evaluate the feasibility of perioperative oral creatine supplementation and to explore its effects on cognitive function and physiological responses to surgery in older adults. Creatine is commonly used to enhance athletic performance, but it can also have positive effects on the brain. Since surgery can alter thinking, memory, and attention patterns in some patients, we will assess whether creatine affects these changes in older adults undergoing surgery.
Protocol Amendment History 7 changes
critical Primary endpoint(s) modified 2026-07-23
notable Enrollment increased: 80 -> 120 participants 2026-07-23
minor Trial arms changed: 1 -> 2 2026-07-23
notable Primary completion pushed: 2028-06-30 -> 2028-08-30 2026-07-23
minor Completion pushed: 2028-06-30 -> 2028-08-30 2026-07-23
notable Primary completion pushed: 2027-12-31 -> 2028-06-30 2026-04-22
minor Completion pushed: 2027-12-31 -> 2028-06-30 2026-04-22
Trial Details
NCT Number NCT07310043
Lead Sponsor Massachusetts General Hospital
Conditions Neurocognitive Disorders, Postoperative Delirium
Enrollment 120 participants
Start Date 2026-09-01
Primary Completion 2028-08-30 (estimated)
Study Completion 2028-08-30 (estimated)
Updated on ClinicalTrials.gov 2026-08-10