Exercise Training and Vitamin D Metabolism

The prevalence of Vitamin D deficiency is significantly higher in adults with overweight/obesity compared to those with normal body mass index (BMI). The "entrapment" of Vitamin D in adipose tissue due to impaired lipolytic stimulation and/or adipose tissue dysfunction has been proposed as the driving mechanism. Exercise training has been proposed as a promising strategy to increase mobilization of Vitamin D from adipose tissue, given its well described role in stimulating lipolysis. Indeed, a recent study revealed that participation in moderate-intensity cardiovascular type exercise over winter can mitigate the decline in 25-hydroxyvitamin D \[25(OH)D\] in adults with overweight/obesity, independent of weight loss. The aim of this study is to investigate the impact of hybrid-type high-intensity interval training over winter on vitamin D metabolism, in adults with overweight/obesity.

NCT Number	NCT07300332
Lead Sponsor	University of Thessaly
Conditions	Obesity & Overweight, Vitamin D
Enrollment	30 participants
Start Date	2025-11-10
Primary Completion	2026-01-31 (estimated)
Study Completion	2026-07-20 (estimated)
Updated on ClinicalTrials.gov	2026-05-26