Uniting Trusted Community Messengers to Improve Access to Cervical Cancer Screening in Rural North Carolina

The purpose of this study is to test the feasibility and acceptability of a multi-level, community-engaged intervention to increase access to cervical cancer screening using human papillomavirus (HPV) self-collection (HPVSC) outreach among women living in a high-risk rural county and to improve navigation for follow-up screening. A one-group intervention evaluation design will be used to pilot test feasibility and acceptability and to assess the proportion of women who return HPVSC kits and test HPV-positive. At the community level, local community-based organizations (CBOs) will serve as HPVSC kit distribution sites. At the individual level, trained community health workers will work with CBOs to support women throughout the HPVSC process, including specimen collection, kit return, result notification, and follow-up clinic-based screening for women who test HPV-positive.

NCT Number	NCT07294066
Lead Sponsor	UNC Lineberger Comprehensive Cancer Center Collaborators: National Institute on Minority Health and Health Disparities (NIMHD)
Conditions	Cervix Cancer, Screen HPV-positive
Enrollment	112 participants
Start Date	2026-07
Primary Completion	2029-01 (estimated)
Study Completion	2029-03 (estimated)
Updated on ClinicalTrials.gov	2026-06-23