Neurobehavioral Changes Following Spaceflight Stressors

This study aims to investigate the impairing effects of known central nervous system (CNS) stressors in a controlled environment in order to predict and mitigate analogous risks in spaceflight. Up to 56 healthy individuals aged 25-60 will spend approx. 110 hours in a laboratory, where they will be exposed to 27 hours of sleep deprivation and will consume alcohol to reach a BAC of 0.08 on a separate day. They will perform cognitive and sensorimotor tasks and undergo MRIs and blood draws.

NCT Number	NCT07293494
Lead Sponsor	University of Pennsylvania Collaborators: Uniformed Services University of the Health Sciences, University of Florida, Cornell University/Weill Cornell Medical Center, National Aeronautics and Space Administration (NASA), University of Nevada, Las Vegas, Loma Linda University
Conditions	Stressor, Individual, Alcohol Impairment, Sleep Deprivation, Impairment, Cognitive
Enrollment	56 participants
Start Date	2026-08-04
Primary Completion	2029-12 (estimated)
Study Completion	2029-12 (estimated)
Updated on ClinicalTrials.gov	2026-08-06