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Fibroblast Line Evaluation for COL5A eXpression and Thoracic Aortic Aneurysms: in Vitro Characterization of Cutaneous Fibroblasts in Adult Patients

Study acronym: FLEX5 project
StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗

Record History

  1. Recruitment opened Start date changed from estimate of Jan 13, 2026 to Jun 24, 2026 · Site details revisedv3 Show 2 more changesShow less
    • Start date changed from estimate of Jan 13, 2026 to Jun 24, 2026
    • Site details revised
  2. Study description shortened, about 8 words Study title revisedv2 Show 1 more changeShow less
    • Study title revised

    See this version in full on ClinicalTrials.gov ↗

  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study examines adults with COL5A gene mutations to understand why some develop aortic aneurysms while others do not. Participants provide a small skin biopsy, and researchers analyze fibroblasts to evaluate collagen production, extracellular matrix organization, and connective-tissue signaling pathways. The goal is to identify biological differences that may explain variable vascular risk and support future personalized monitoring and treatment strategies.
Trial Details
NCT Number NCT07282717
Lead Sponsor IRCCS Policlinico S. Donato
Conditions Mutations Affecting the COL5A Gene, Aneurysm Aortic
Enrollment 20 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov