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ZYNRELEF vs Continuous Catheter for Pain Management Following Shoulder Arthroplasty

StatusEnrolling by Invitation
PhasePhase 4
Started2026-02-14
View on ClinicalTrials.gov ↗
The purpose of this study is to determine if local intra-operative application of ZYNRELEF (topical medication) during shoulder replacement surgery improves pain control (as defined by opioid consumption after surgery) compared to the use of an interscalene block with catheter. This is a randomized clinical trial without blinding. Subjects will complete patient reported outcomes before and after surgery. Subjects will track their narcotic use, pain scores and pain satisfaction after surgery.

Amendment record

Amended once since 2025-12-02. Every amendment is listed below.

Dates here are the day the sponsor filed the amendment, not the day ClinicalTrials.gov published it. Version history last read from ClinicalTrials.gov on 2026-08-30.

2026-02-17
Amendment Not Yet Recruiting→Enrolling by Invitation Study Status, Contacts/Locations v1
2025-12-02
Original filing
Trial Details
NCT Number NCT07280195
Lead Sponsor Washington University School of Medicine
Conditions Total Shoulder Arthroplasty, Pain Management
Enrollment 86 participants
Start Date 2026-02-14
Primary Completion 2026-12 (estimated)
Study Completion 2027-12 (estimated)
Updated on ClinicalTrials.gov 2026-02-19