ZYNRELEF vs Continuous Catheter for Pain Management Following Shoulder Arthroplasty

The purpose of this study is to determine if local intra-operative application of ZYNRELEF (topical medication) during shoulder replacement surgery improves pain control (as defined by opioid consumption after surgery) compared to the use of an interscalene block with catheter. This is a randomized clinical trial without blinding. Subjects will complete patient reported outcomes before and after surgery. Subjects will track their narcotic use, pain scores and pain satisfaction after surgery.

NCT Number	NCT07280195
Lead Sponsor	Washington University School of Medicine
Conditions	Total Shoulder Arthroplasty, Pain Management
Enrollment	86 participants
Start Date	2026-02-14
Primary Completion	2026-12 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2026-02-19