Clinical Trial

Sparing Parotid Ducts Via MRI Sialography for Reduced Patient-Reported Xerostomia

Recruiting Phase 2
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Summary
Radiation-induced xerostomia (dry mouth) is one of the most common and severe side effects for patients receiving radiation therapy for head and neck cancer. New approaches are needed to reduce this side effect and improve patients' quality of life after treatment. This is a Phase II, single-center, double-masked, parallel-arm, randomized controlled trial. It compares MRI-guided parotid ductal sparing to the standard approach of mean parotid gland sparing, focusing on patient-reported dry mouth outcomes in individuals receiving definitive radiotherapy for oropharyngeal cancer.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-12-03; most recent amendment 2026-02-02.
Status change: Not Yet Recruiting → Recruiting 2026-02-02
Trial Details
NCT Number NCT07278557
Lead Sponsor UNC Lineberger Comprehensive Cancer Center
Collaborators: National Institute of Dental and Craniofacial Research (NIDCR)
Conditions Head and Neck Cancer
Enrollment 98 participants
Start Date 2026-01-28
Primary Completion 2030-02 (estimated)
Study Completion 2030-02 (estimated)
Updated on ClinicalTrials.gov 2026-02-03