Clinical Trial

Promoting Recovery After Brain Injury Using Focused Ultrasound

Study acronym: ReBOUND
Recruiting
View on ClinicalTrials.gov →
Summary
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this project aims to (1) determine neurobehavioral responses to low-intensity focused ultrasound (LIFUP) in patients with disorders of consciousness (DoC) following brain injury, (2) determine neurophysiologic (EEG) responses to LIFUP in patients with DoC and (3) identify and evaluate ethical perspectives of patient representatives (family members and surrogate decision-makers) surrounding investigation of therapeutic neuromodulation technologies such as LIFUP in patients with DoC.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-12-02; most recent amendment 2026-06-12.
Status change: Not Yet Recruiting → Recruiting 2026-02-13
Trial Details
NCT Number NCT07277309
Lead Sponsor Massachusetts General Hospital
Collaborators: National Institute of Neurological Disorders and Stroke (NINDS)
Conditions Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Enrollment 36 participants
Start Date 2026-05-26
Primary Completion 2029-07 (estimated)
Study Completion 2029-07 (estimated)
Updated on ClinicalTrials.gov 2026-06-15