Clinical Trial

A Study of GSK5764227 in Combination With Standard of Care (SoC) or Other Agents in Participants With Advanced Solid Tumors

Recruiting Phase 1
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Record status
This record was last updated January 7, 2026 (before its estimated July 13, 2026 completion). Its status may not reflect the trial's current state.
Summary
The goal of this clinical trial is to test a new medicine called GSK5764227, which delivers a toxin directly to cancer cells to destroy them while sparing healthy cells. The study will combine GSK5764227 with standard treatments to evaluate its safety, examine how the body processes it, check if it triggers any immune responses, and assess whether it can shrink or control cancer.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-12-02.
Status change: Not Yet Recruiting → Recruiting 2026-01-05
Trial Details
NCT Number NCT07277270
Lead Sponsor GlaxoSmithKline
Conditions Neoplasms
Enrollment 84 participants
Start Date 2025-12-03
Primary Completion 2026-07-13 (estimated)
Study Completion 2028-09-29 (estimated)
Updated on ClinicalTrials.gov 2026-01-07