Clinical Trial

Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations

Study acronym: INSPIRE-COPD-E
Not Yet Recruiting Phase 1
View on ClinicalTrials.gov →
Summary
The purpose of this study is to investigate the safety and tolerability of Metformin and how it changes blood markers associated with aging in persons who have chronic obstructive pulmonary disease (COPD) who do not have diabetes.
Protocol Amendment History 2 changes
notable Primary completion pushed: 2027-03-31 -> 2028-09-01 2026-04-30
minor Completion pushed: 2027-09-30 -> 2029-10-02 2026-04-30
Trial Details
NCT Number NCT07275359
Lead Sponsor Duke University
Collaborators: National Institute on Aging (NIA)
Conditions Chronic Obstructive Pulmonary Disease (COPD)
Enrollment 45 participants
Start Date 2026-09-01
Primary Completion 2028-09-01 (estimated)
Study Completion 2029-10-02 (estimated)
Updated on ClinicalTrials.gov 2026-04-29